The monoaminergic hypothesis of depression has provided the basis for extensive research into the pathophysiology of mood disorders and has been of great significance for the development of effective antidepressants.Current antidepressant treatments not only increase serotonin and/or noradrenaline bioavailability but also originate adaptive changes
In the context of generation of lubrication flows, gear pumps are widely used, with gerotor-type pumps being specially popular, given their low cost, high compactness, and reliability.The design process of gerotor pumps requires the simulation of the fluid dynamics phenomena that characterize the fluid displacement by the pump.Designers and researc
PIWI-interacting RNAs (piRNAs) direct Piwi to repress transposons and maintain genome integrity in Drosophila ovarian somatic cells.piRNA maturation and association with Piwi occur at perinuclear Yb 2004 bmw 325i hood bodies, the centers of piRNA biogenesis.Here, we show that piRNA intermediates arising from the piRNA cluster flamenco (flam) locali
This study was designed to determine whether nano-sized ZnO has the potential to cause acute cutaneous irritation using cultured HaCaT keratinocytes and a human skin equivalent as in vitro models, compared to non-nanomaterials.Commercial nano ZnO with different sizes (50 nm and 100 nm) was characterized by dynamic light scattering caroline gardner
The dopaminergic system is known to be involved in working memory processed by several brain regions like prefrontal cortex (PFC), hippocampus, striatum.In an earlier study we could show that Levodopa but not Modafinil enhanced working memory in a T-maze only during the early phase of training (day 3), whereas the later phase remained unaffected.Ra